Product Name :
Phospho-p130 (T986) Recombinant Rabbit Monoclonal Antibody [JE64-95]
Predicted band size :
128 kDa
Observed band size :
130 kDa
Synonyms:
130 kDa retinoblastoma associated protein antibody 130 kDa retinoblastoma-associated protein antibody IB4 antibody p130 antibody PPAR-alpha-interacting complex protein 128 antibody PRB2 antibody Rb2 antibody Rbl2 antibody RBL2_HUMAN antibody RBR 2 antibody 展开
Function :
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 ‘Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phosphopeptide corresponding to residues around Thr986 of human p130.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
JE64-95
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.VcMMAE site Aliquot store at -20℃.173252-76-1 Price Avoid repeated freeze / thaw cycles.PMID:33399351
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 128 kDa
Positive control :
Jurkat cell lysate, K-562 cell lysate, NIH/3T3 cell lysate, C2C12 cell lysate, PC-12 cell lysate, human appendix tissue, human colon cancer tissue, mouse colon tissue, rat colon tissue.