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Original ArticleDiffusion-weighted EPI- and HASTE-MRI and 18F-FDG-PET-CT early during chemoradiotherapy in advanced head and neck cancerCharlotte S. Schouten1, Remco de Bree1, Lisa van der Putten1, Daniel P. Noij2, Otto S. Hoekstra2, Emile F.I. Comans2, Birgit I. Witte3, Patricia A. Doornaert4, C. Ren?Leemans1, Jonas A. CastelijnsDepartment of Otolaryngology-Head and Neck Surgery, 2Department of Radiology and Nuclear Medicine, 3Department of Epidemiology andBiostatistics, 4Department of Radiation Oncology, VU University Health-related Center, Amsterdam, the Netherlands Correspondence to: Prof. Dr. Jonas A. Castelijns. Division of Radiology and Nuclear Medicine, VU University Healthcare Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. E mail: [email protected] issue: Diffusion-weighted MRI (DW-MRI) has potential to predict chemoradiotherapy (CRT) response in head and neck squamous cell carcinoma (HNSCC) and is commonly performed employing echoplanar imaging (EPI). On the other hand, EPI-DWI is susceptible to geometric distortions. Half-fourier acquisition single-shot turbo spin-echo (HASTE)-DWI might be an option. This potential pilot study evaluates the possible predictive value of EPI- and HASTE-DWI and 18F-fluorodeoxyglucose PET-CT (18F-FDGPET-CT) early during CRT for locoregional outcome in HNSCC. Approaches: Eight sufferers with sophisticated HNSCC (7 principal tumors and 25 nodal metastases) scheduled for CRT, underwent DW-MRI (utilizing each EPI- and HASTE-DWI) and 18F-FDG-PET(-CT) pretreatment, early during treatment and 3 months immediately after treatment. Median follow-up time was 38 months. Results: No local recurrences were detected through follow-up. Median Apparent Diffusion Coefficient (ADC)EPI-values in principal tumors elevated from 77?0? mm2/s pretreatment, to 113?0? mm2/s for the duration of therapy (P=0.02), whereas ADCHASTE did not increase (74 and 74 mm2/s, respectively). Two regional recurrences had been diagnosed. During therapy, ADCEPI tended to become larger for individuals with regional manage [(117.three?2.1)?0 ? mm 2/s] than for patients with a recurrence [(98.4-(Diethylphosphinyl)benzenamine site 0?.(R)-2-Chloro-2-fluoroacetic acid Price two)?0 ? mm 2/s]. This difference was not noticed with ADCHASTE. No correlations involving ADCEPI and SUV (Standardized Uptake Worth) have been identified within the primary tumor or nodal metastases. Conclusions: HASTE-DWI appears to become inadequate in early CRT response prediction, in comparison to EPIDWI which has potential to predict locoregional outcome.PMID:33558991 EPI-DWI and 18F-FDG-PET-CT potentially give independent information and facts within the early response to treatment, because no correlations had been discovered between ADCEPI and SUV.Search phrases: Chemoradiotherapy (CRT); diffusion-weighted magnetic resonance imaging (DW-MRI); head and neck squamous cell carcinoma (HNSCC); positron emission tomography (PET); remedy response Submitted May possibly 23, 2014. Accepted for publication Jul 25, 2014. doi: 10.3978/j.issn.2223-4292.2014.07.15 View this short article at: http://dx.doi.org/10.3978/j.issn.2223-4292.2014.07.?AME Publishing Firm. All rights reserved.amepc.org/qimsQuant Imaging Med Surg 2014;4(4):239-Schouten et al. DW-MRI and 18F-FDG-PET-CT early for the duration of CRT in HNSCCIntroduction Patients with resectable sophisticated staged head a.
