Product Name :
SHP2 Recombinant Rabbit Monoclonal Antibody [SN72-02]
Predicted band size :
68 kDa
Observed band size :
68 kDa
Synonyms:
BPTP3 antibody CFC antibody JMML antibody METCDS antibody MGC14433 antibody NS1 antibody OTTHUMP00000166107 antibody OTTHUMP00000166108 antibody Protein tyrosine phosphatase 2 antibody Protein tyrosine phosphatase 2C antibody 展开
Function :
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus .Positively regulates MAPK signal transduction pathway.Dephosphorylates GAB1, ARHGAP35 and EGFR.Dephosphorylates ROCK2 at ‘Tyr-722’ resulting in stimulation of its RhoA binding activity.Dephosphorylates CDC73.Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within N-terminal human SHP2.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IP, IHC-P
Coupling :
unconjugated
Clone number:
SN72-02
RRID:
AB_3070013
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Formula of 1130365-33-1 Aliquot store at -20℃ or -80℃.5-Bromo-7-chloro-1H-indole In stock Avoid repeated freeze / thaw cycles.PMID:33682561
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 68 kDa
Positive control :
K-562 cell lysate, 293T cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, mouse heart tissue lysate, rat brain tissue lysate, rat heart tissue lysate, human tonsil tissue, mouse testis tissue, rat testis tissue.