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Tumor Biol.Spiro[3.3]heptan-2-amine hydrochloride site (2012) 33:607?15 DOI 10.PMID:33744416 1007/s13277-012-0316-RESEARCH ARTICLEPET imaging with radiolabeled antibodies and tyrosine kinase inhibitors: immuno-PET and TKI-PETGuus A. M. S. van Dongen Alex J. Poot Danielle J. VugtsReceived: 19 October 2011 / Accepted: three January 2012 / Published on the web: 21 January 2012 # The Author(s) 2012. This article is published with open access at SpringerlinkAbstract Through the last decade, the discovery of essential tumor targets has boosted the design of targeted therapeutic agents with monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKIs) receiving many of the attention. Immuno-positron emission tomography (immuno-PET) and TKI-PET, the in vivo tracking and quantification of mAbs and TKIs biodistribution with PET, are fascinating novel solutions for superior understanding on the in vivo behavior and efficacy of these targeted drugs in person individuals and for a lot more effective drug development. Extremely recently, existing excellent manufacturing practice compliant procedures for labeling of mAbs with positron emitters happen to be described, too because the preparation of some radiolabeled TKIs, while the very first proof of principle studies has been performed in patients. In this critique, technical developments in immunoPET and TKI-PET are described, and their clinical potential is discussed. An overview is supplied for the most attractive preclinical immuno-PET and TKI-PET research, also because the initially clinical achievements with these emerging technologies. Keywords Positron emission tomography . Monoclonal antibodies . Tyrosine kinase inhibitors . Zirconium-89 . Fluorine-18 . Carbon-G. A. M. S. van Dongen (*) : A. J. Poot : D. J. Vugts Division of Otolaryngology/Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands e-mail: gams.vandon.
